Blar i forfatter "Guz, Katarzyna"

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    • Fetal/Neonatal Alloimmune Thrombocytopenia: Pathogenesis, Diagnostics and Prevention 

      Brojer, Eva; Husebekk, Anne; Debska, Marzena; Uhrynowska, Malgorozata; Guz, Katarzyna; Orzinska, Agnieszka; Debski, Romuald; Maslanka, Krystyna (Journal article; Tidsskriftartikkel; Peer reviewed, 2015-11-12)
      Fetal/neonatal alloimmune thrombocytopenia (FNAIT) is a relatively rare condition (1/1000–1/2000) that was granted orphan status by the European Medicines Agency in 2011. Clinical consequences of FNAIT, however, may be severe. A thrombocytopenic fetus or new-born is at risk of intracranial hemorrhage that may result in lifelong disability or death. Preventing such bleeding is thus vital and requires ...

    • Identification and follow-up of pregnant women with platelet-type human platelet antigen (HPA)-1bb alloimmunized with fetal HPA-1a 

      Dębska, Marzena; Małgorzata, Uhrynowska; Guz, Katarzyna; Kopeć, Izabella; Lachert, Elżbieta; Orzińska, Agnieszka; Kretowicz, Piotr; Antoniewicz-Papis, Jolanta; Dębski, Romuald; Łętowska, Magdalena; Husebekk, Anne; Brojer, Ewa (Journal article; Tidsskriftartikkel; Peer reviewed, 2016-11-15)
      <p><i>Introduction</i>: Pregnant women negative for human platelet antigen 1a (HPA-1a) are at risk of alloimmunization with fetal HPA-1a antigen inherited from the father, and their offspring may develop fetal and neonatal alloimmune thrombocytopenia (FNAIT). The aim of this study was to analyze the frequency of HPA-1a alloimmunization in pregnant Polish women, the feasibility of using maternal ...

    • Platelet alloimmunization is associated with low grade chronic histiocytic intervillositis - A new link to a rare placental lesion? 

      Nedberg, Nora Hersoug; Turowski, Gitta Erika; Guz, Katarzyna; Przytuła, Ewa; Uhrynowska, Małgorzata; Roald, Borghild; Husebekk, Anne; Sitras, Vasilis; Nystad, Mona; Dębska, Marzena; Brojer, Ewa; Tiller, Heidi (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-07-23)
      <i>Introduction</i> - Maternal alloimmunization against human platelet antigen (HPA)-1a has been implied to mediate both reduced birth weight and chronic placental inflammation. Fetal growth restriction is associated with different types of chronic inflammation in the placenta, mainly chronic histiocytic intervillositis and chronic villitis. The aim of this prospective study was to do a systematic ...

    • What's with the boys? Lower birth weight in boys from HPA-1a alloimmunized pregnancies – New insights from a large prospective screening study in Poland 

      Coucheron, Tina; Uhrynowska, Malgorzata; Guz, Katarzyna; Orzińska, Agnieszka; Debska, Marzena; Gierszon, Agnieszka; Ahlen, Maria Therese; Bertelsen, eirin listau; Berge, gerd; Husebekk, Anne; Brojer, Ewa; Tiller, Heidi (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-11-07)
      Fetomaternal incompatibility in human platelet antigens (HPAs) can cause maternal alloimmunization, which in turn may lead to thrombocytopenia with or without intracranial hemorrhage (ICH) in the fetus or newborn. Retrospective studies suggest that boys from alloimmunized mothers may have higher risk of ICH and lower birth weight than girls. The objective of this study was to assess how maternal ...